There are a number of factors which make detection of ocular herpes a daunting task. We are going to cover some of them.
Conditions to consider in the differential diagnosis of HSV keratitis include the following:
| Disorder groups | Disorders | 
|---|---|
| Corneal dystrophies | 
 | 
| Autoimmune disorders | 
 | 
| Malacia | 
 | 
| Other infections | 
 | 
| Herpes associated with other infections (mixed infections) | 
 | 
| Infections with other types of herpesviruses | 
 | 
Proper differential diagnosis requires thorough history taking, virology tests, serological and bacterial tests (if needed), as well as corneal scraping and sometimes biopsy. Confocal microscopy may be a viable diagnostic technique if acanthamoeba is suspected.